In this paper, we describe a novel clinical breast diffuse optical tomography (DOT) instrument for CW and RF data acquisition in transmission geometry. It is designed to be able to acquire a massive amount of data in a short amount of time available for patient measurement by using a 209-channel galvo-based fast optical switch and a fast electron-multiplying CCD. In addition to CW measurements, RF measurements were made by using an electro-optic modulator for source modulation and a gain-modulated image intensifier for detection. The patient bed has many clinically-oriented features as well as improved data acquisition rate and transmission RF measurement capability. A series of preliminary results will be shown, including a heterodyne RF experiment for bulk property measurement and a CW experiment for 3D imaging. In order to deal with large data size, a linear reconstruction algorithm that exploits separability of the inverse problem in Fourier domain is used for fast and memory-load-free reconstruction.
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