Abstract

The ability of multi-modal optical spectroscopy to detect signals from pancreatic tissue was demonstrated by studying human pancreatic cancer xenografts in mice and freshly excised human pancreatic tumor tissue. Measured optical spectra and fluorescence decays were correlated with tissue morphological and biochemical properties. The measured spectral features and decay times correlated well with expected pathological differences in normal, pancreatitis and adenocarcinoma tissue states. The observed differences between the fluorescence and reflectance properties of normal, pancreatitis and adenocarcinoma tissue indicate a possible application of multi-modal optical spectroscopy to differentiating between the three tissue classifications.

© 2007 SPIE

PDF Article
More Like This
Modeling Reflectance and Fluorescence Spectra of Human Pancreatic Tissues for Cancer Diagnostics

Robert H. Wilson, Malavika Chandra, James Scheiman, David Heidt, Diane Simeone, Barbara McKenna, and Mary-Ann Mycek
FTuK5 Frontiers in Optics (FiO) 2008

Optical spectroscopy for quantitative sensing in human pancreatic tissues

Robert H. Wilson, Malavika Chandra, William Lloyd, Leng-Chun Chen, James Scheiman, Diane Simeone, Barbara McKenna, and Mary-Ann Mycek
808713 European Conference on Biomedical Optics (ECBO) 2011

Optical spectroscopy for clinical detection of pancreatic cancer

Malavika Chandra, Robert H. Wilson, James Scheiman, Diane Simeone, Barbara McKenna, Julianne Purdy, and Mary-Ann Mycek
7368_1G European Conference on Biomedical Optics (ECBO) 2009

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription