Abstract

Most women with early breast cancer have the option of breast conserving therapy, which involves the complete removal of the primary breast lesion (a lumpectomy) with tumor-free margins, followed by radiotherapy. Since the presence of tumor at or near the margin is strongly correlated with the risk of local tumor recurrence, there is a need to develop a non-invasive, real-time tool that can differentiate normal breast tissue from tumor at the margins to assure complete removal. Our previous studies have demonstrated the ability of combined autofluorescence and diffuse reflectance spectroscopy to differentiate normal from non-normal breast tissue ex vivo. Using a portable, combined fluorescence and reflectance spectroscopy system, measurements were taken from each of the six surfaces of the tissue mass immediately following removal during lumpectomies for 24 patients. After correlation with histopathology, a multivariate statistical algorithm classified the 27 tumor spectra and 102 normal spectra with 78% sensitivity and 99% specificity, or 94% negative and 95% positive predictive value. Since point spectroscopy is ultimately insufficient for this application due to its small sampling area, fluorescence and reflectance spectral images from a lumpectomy specimen were gathered and used to show the feasibility of this approach.

© 2007 SPIE

PDF Article
More Like This
Fluorescence and Reflectance Spectroscopy and Spectral Imaging for Evaluating Surgical Margin Status during Breast Cancer Resection

Matthew D. Keller, Shovan K. Majumder, Mark C. Kelley, Ingrid M. Meszoely, Fouad I. Boulous, and Anita Mahadevan-Jansen
BSuB6 Biomedical Optics (BIOMED) 2008

Optical Guidance of Brain Therapies

Anita Mahadevan-Jansen
TuF1_2 Conference on Lasers and Electro-Optics/Pacific Rim (CLEOPR) 2007

Optical spectroscopy for intra-operative guidance of brain tumor resection

Wei-Chiang Lin, E. Duco Jansen, Anita Mabadevan-Jansen, and Steven A. Toms
SuD2 Biomedical Optical Spectroscopy and Diagnostics (BOSD) 2000

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription