Noninvasive ophthalmic angiography is demonstrated for the in vivo human. Three-dimensional structural and flow imaging have been performed with a high-speed spectral-domain optical coherence tomography. The two methods are presented; (1) Doppler optical coherence angiography: three-dimensional vasculature of retinal and choroidal vessels are visualized by flow imaging; and, (2) scattering optical coherence angiography: the choroidal vasculature is segmented from three-dimensional OCT volume set. By integrating three-dimensional vasculature images, two-dimensional images of blood vessels are obtained. These are corresponding to fluorescein angiogram and indocyanine green angiogram.
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