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Conferences > ECBO > 2005 > PDB > PDB8

Cross-sectional Imaging of Functional Activation in the Rat Somatosensory Cortex with Optical Coherence Tomography

A.D. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D.A. Boas, and J.G. Fujimoto

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Abstract

Simultaneous optical coherence tomography (OCT) and video microscopy were performed on the rat somatosensory cortex through a thinned skull during forepaw stimulation. Fractional change measurements in OCT images reveal a functional signal timecourse similar to well understood hemodynamic signal timecourses measured with video microscopy. The precise etiology of the observed OCT functional signal is still under investigation, but these results suggest that OCT can provide high-resolution cross-sectional images of functional neuro-vascular activation.

© 2005 Optical Society of America

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