Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases.

J. Smith; C. Kendall; J. Christie-Brown; A. Sammon; N. Stone

doi:10.1364/ECBO.2003.5141_305

Diagnostic Optical Spectroscopy in Biomedicine II
Proc. SPIE (Optica Publishing Group, 2003),
paper 5141_305
•https://doi.org/10.1364/ECBO.2003.5141_305

Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases.

J. Smith, C. Kendall, J. Christie-Brown, A. Sammon, and N. Stone

European Conference on Biomedical Optics 2003

Munich Germany
ISBN: 0-8194-5011-1

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J. Smith, C. Kendall, J. Christie-Brown, A. Sammon, and N. Stone, "Raman Spectroscopy in the assessment of breast cancer and axillary lymph node metastases.," in Diagnostic Optical Spectroscopy in Biomedicine II, G. Wagnières, ed., Vol. 5141 of Proc. SPIE (Optica Publishing Group, 2003), paper 5141_305.

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Abstract

Raman spectroscopy is an optical diagnostic technique applied in this study to characterize breast tissue by biochemical signature spectra. In cross-validated results, Raman spectroscopy identifies invasive breast carcinoma with 75–97% agreement with histopathology opinion. Axillary lymph nodes from patients with breast carcinoma were mapped with confocal Raman spectroscopy and colour-weighted principal component analysis (PCA) images were used to identify local biochemical features and correlate these with parallel section slides analysed with routine histology.

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