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Three-Dimensional Quantification of Collagen Fibers in Cancer Metastases within the Peritoneal Cavity

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Abstract

We develop a metric, 3D directional variance, as a quantitative biomarker of truly 3D collagen organization. We demonstrate how this metric can quantify differences in collagen organization between human normal peritoneum and potential metastases.

© 2016 Optical Society of America

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