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  • 2017 European Conference on Lasers and Electro-Optics and European Quantum Electronics Conference
  • (Optica Publishing Group, 2017),
  • paper CM_CL_1_3

Large-scale production of scaffolds for stem cell expansion fabricated by two-photon polymerization

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Abstract

Stem cells are a promising tool for regenerative medicine and in the study of new therapies based on their secreted products, which modulate the immune system response and help tissue repair. The research on human patients in this field is slowed down by the limited availability of human stem cells, since the expansion of those cells is usually performed with exogenous substances or with the use of feeder layers, to prevent loss of pluripotency during cell expansion. The cells obtained with chemical conditioning are a good model for in vitro studies, but they are not considered safe for implantation [1]. An alternative way to expand stem cells, without any external biochemical conditioning, is based on the mechanical conditioning by a microstructured culture substrate, that mimics the structure of the staminal niches, which are the microenvironment where stem cells are maintained in our body.

© 2017 IEEE

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