Abstract

Biophotonics represents a very attractive and promising field of interest for biosensing applications [1]. Hybrid optical fibers bearing specific probes for DNA detection are advanced tools in which the sensing element can be integrated in a microfluidic device for the generation of optical signals [2, 3]. In particular, Photonic Crystal Fibers (PCFs) have the unique feature of presenting a cross-section defined by air-hole arrays, allowing to perform internal functionalization [4, 5]. In this work, the feasibility of a novel specific DNA sensing platform, based on the use of PCFs bearing a Bragg grating, is described, together with a strategy for enhancement of the optical signal based on the use of gold nanoparticles (Au NPs). Very specific Peptide Nucleic Acid (PNA) probes, Oligonucleotide (ON) mimics that are well suited for specific DNA target sequences detection, have been used due to their highly favourable properties in DNA hybridization and chemical and biological stability.

© 2013 IEEE

PDF Article
More Like This
Label-free DNA detection with PNA modified long period fiber grating-based sensor

M. Sozzi, A. Cucinotta, R. Corradini, R. Marchelli, M. Konstantaki, S. Pissadakis, and S. Selleri
JSIV1_2 European Quantum Electronics Conference (EQEC) 2011

Selective detection of labeled DNA using an air-clad photonic crystal fiber

J. B. Jensen, P.E. Hoiby, L.H. Pedersen, J.R. Folkenberg, and A. Bjarklev
CWM2 Conference on Lasers and Electro-Optics (CLEO) 2004

DNA detection using a photonic crystal waveguide sensor

V. Toccafondo, J. García Rupérez, M. J. Bañuls, A. Griol, J. G. Castelló, S. Peransi Llopis, and A. Maquieira
SWB3 Optical Sensors (Sensors) 2010

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription