Abstract
In this communication, the intrinsic precision in the localization of a fluorescent source in a turbid medium is analyzed for various fluorescence diffuse optical tomography (fDOT) setups in reflection geometry via a rigorous statistical methodology, the Cramér-Rao Bound [1,2]. Firstly, a spatially and temporally resolved imaging technique (TD) is considered and the strong impact of the fluores-cence life-time is revealed. Then, these performances are compared with other standard setups, namely a spatially resolved in a continuous wave setup (CW) and a single detector in a time resolved setup (ITD).
© 2011 Optical Society of America
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