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  • CLEO/Europe and EQEC 2011 Conference Digest
  • OSA Technical Digest (CD) (Optica Publishing Group, 2011),
  • paper CLEB_P7

Intrinsic precision limit in steady-state and time-domain fluorescence diffuse optical imaging

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Abstract

In this communication, the intrinsic precision in the localization of a fluorescent source in a turbid medium is analyzed for various fluorescence diffuse optical tomography (fDOT) setups in reflection geometry via a rigorous statistical methodology, the Cramér-Rao Bound [1,2]. Firstly, a spatially and temporally resolved imaging technique (TD) is considered and the strong impact of the fluores-cence life-time is revealed. Then, these performances are compared with other standard setups, namely a spatially resolved in a continuous wave setup (CW) and a single detector in a time resolved setup (ITD).

© 2011 Optical Society of America

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