Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • CLEO/Europe and EQEC 2011 Conference Digest
  • OSA Technical Digest (CD) (Optica Publishing Group, 2011),
  • paper CH4_2

DNA Immobilisation and Hydrogel Matrix Formation in Suspended-Core Optical Fibre

Not Accessible

Your library or personal account may give you access

Abstract

Recently, microstructured optical fibres (MOFs) have been proposed for sensing [1-3] in a number of new applications made possible by their unique cladding structure. The analyte can be introduced into the fibre voids, where confinement of the sample within the optical mode enhances its interaction with the optical field and allows tailoring of the sensor length. In order to maximize the light interaction with the sample, the sample should be reasonably uniformly distributed inside the fibre so that variations in the refractive index do not inhibit light guidance. Therefore, we have proposed the use of a specifically designed hydrogel for anchoring the analyte within a fibre and we have reported previously such hydrogel formation within a hollow-core photonic crystal fibre (HC-PCF) [3]. In this paper we extend our earlier work to a suspended-core optical fibre with an incircle core diameter of 1.2μm, shown in Fig.1 (a). We believe that it will be possible to achieve more effective hydrogel coverage in suspended-core fibre than in HC-PCF. The improved guidance of the light used for the photo-polymerization step of hydrogel formation should produce a hydrogel matrix over a greater length of fibre. Moreover, it is expected that the hydrogel matrix will only partially fill the cladding holes, which should help retain the guiding properties of the fibre at the wavelengths of interest and thus enhance the interaction length. Furthermore, the incomplete filling of the voids in the fibre structure should promote access by the analyte to the hydrogel matrix, which will improve the efficiency of DNA probe hybridisation. In this paper, we show for the first time the formation of a hydrogel matrix in a suspended-core fibre and demonstrate its ability to immobilize a DNA probe.

© 2011 Optical Society of America

PDF Article
More Like This
A Comparison Between Multimode Tip And Suspended Core Fluorescence Optical Fibre Sensors

E. P. Schartner, G. Tsiminis, M. R. Henderson, M. R. Hutchinson, and T. M. Monro
CH_5_6 The European Conference on Lasers and Electro-Optics (CLEO/Europe) 2015

Long-Period Fibre Grating Based Biosensor For Detection of DNA Hybridisation

Xianfeng Chen, Marcus Hughes, Kaiming Zhou, Edward Davies, Lin Zhang, Anna Hine, and Ian Bennion
BTuE4 Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides (BGPP) 2007

Enzyme Immobilised Coatings for Glucose Optical Fibre Sensors

P.J. Scully, J. S. Young, O. Podrazky, G. Kuncova, J. Bolyo, V. Matejec, K. Rose, L. Sasek, N. Jaffrezic Renault, S.V. Dzyadevych, R. Fernandez-Lafuente, L. Betancor, and B. O’Kennedy
ThE80 Optical Fiber Sensors (OFS) 2006

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.