Abstract
We used ultrashort pulse durations varying from nanoseconds to femtoseconds to study laser-tissue interaction in nominally absorbing and transparent media and were able to differentiate between intensity and fluence related mechanisms. Our first study of laser-tissue interactions using single high intensity pulses in the femtosecond time regime has shown that minimal retinal effects can only be produced with peak intensities higher than 1011 W/cm2.1 The unique situation for producing minimal tissue effects with extremely high peak intensities provides the opportunity to study nonlinear optical effects like photobleaching and nonlinear light propagation in tissue in vivo without overwhelming the initial effects by high energy tissue destruction. Experiments using pulse energies up to 100 times threshold, corresponding to nominal intensities up to 1013 W/cm2, did not result in essentially more intense tissue effects.
© 1989 Optical Society of America
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