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Wavelength-dependent Second Harmonic Generation Circular Dichroism for Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer

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Abstract

Multi-wavelength excitation SHG microscopy with circular dichroism probes decreasing chirality in fibrillary models of ovarian stroma comprised of collagen I and III isoforms. Results show increased sensitivity with shorter excitation wavelength.

© 2016 Optical Society of America

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