Microglial Responses to Blood Brain Barrier Disruption in Neuroinflammatory Disease

Dimitrios Davalos

doi:10.1364/BRAIN.2016.BTh3D.5

Biomedical Optics 2016
OSA Technical Digest (online) (Optica Publishing Group, 2016),
paper BTh3D.5
•https://doi.org/10.1364/BRAIN.2016.BTh3D.5

Microglial Responses to Blood Brain Barrier Disruption in Neuroinflammatory Disease

Dimitrios Davalos

Optics and the Brain 2016

Fort Lauderdale, Florida United States
25–28 April 2016
ISBN: 978-1-943580-10-1

From the session
Optical Imaging of Models of Brain Disease (BTh3D)

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D. Davalos, "Microglial Responses to Blood Brain Barrier Disruption in Neuroinflammatory Disease," in Biomedical Optics 2016, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper BTh3D.5.

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Abstract

Intravital spinal cord imaging in neuroinflammation identified early microglial responses around disrupted blood vessels. Coagulation activity is required for perivascular microglial activation and neuronal damage, and correlates with vascular disruption, lesion formation and disease severity.

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