Capillary substrate of brain tissue oxygenation changes with age

Mohammad Moeini; Mohammad Moeini; Maryam S Tabatabaei; Ashok Kakkar; Frédéric Lesage; Frédéric Lesage

doi:10.1364/BRAIN.2016.BM4D.2

Biomedical Optics 2016
OSA Technical Digest (online) (Optica Publishing Group, 2016),
paper BM4D.2
•https://doi.org/10.1364/BRAIN.2016.BM4D.2

Capillary substrate of brain tissue oxygenation changes with age

Mohammad Moeini, Maryam S Tabatabaei, Ashok Kakkar, and Frédéric Lesage

Optics and the Brain 2016

Fort Lauderdale, Florida United States
25–28 April 2016
ISBN: 978-1-943580-10-1

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Optical Imaging and Neurovascular Coupling (BM4D)

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M. Moeini, M. S. Tabatabaei, A. Kakkar, and F. Lesage, "Capillary substrate of brain tissue oxygenation changes with age," in Biomedical Optics 2016, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper BM4D.2.

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Abstract

This work aimed to investigate the impact of vascular changes with age on brain tissue oxygenation. In a first set of experiments, we measured capillary RBC dynamics in sensory-motor cortex of young and aged mice under isoflurane-anesthetized conditions and reproduced previous results found in rats. In a separate cohort we then measured the impact of these changes on tissue oxygenation using two-photon lifetime imaging of the phosphorescent probe PtP-C343. Our results show decreased oxygen delivery and brain tissue oxygenation with age suggesting a role for oxygen delivery in cognitive decline.

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