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Nano-imaging for glia-synapse fine structures with a homemade near-field optical microscope

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Abstract

To investigate basic processes responsible for brain functions by nano-imaging of astrocyte-synapse fine structures, we have developed a homemade near-field optical microscope (SNOM) combined with an inverted optical microscope providing nanoscopic views as well as macroscopic ones. Using topographical and fluorescence information from a slice or a cultured sample, we have visualized, for the first time, the fine structures and snapshot of differences of the sample states with/without stimulation of astrocytes due to their interactions and correlations in spatial resolution of λ/10.

© 2015 Optical Society of America

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