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Ultrahigh Resolution Ophthalmic Imaging with Optical Coherence Tomography

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Abstract

In vivo ultrahigh resolution, spectroscopic optical coherence tomography (OCT) with 3µm axial resolution allows for an unprecedented visualization of microstructure relevant to pathology in the anterior eye and retina. The visualization of retinal morphology and intraretinal structures shown here demonstrate the potential for this technique to identify early structural and functional changes associated with retinal diseases, such as diabetic retinopathy and glaucoma. Ultrahigh resolution OCT allows delineation of corneal morphology, including the corneal epithelium and endothelium. Ultrahigh resolution OCT also allows for the imaging of animal models of disease, such as transgenic mice, providing a powerful research tool to better understand disease pathogenesis and evaluate therapies.

© 2000 Optical Society of America

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