Abstract
The incidence and mortality of invasive cervical cancer in North America has decreased by 70% over the last fifty years, because of early detection through screening efforts (1,2). The test characteristics of the Papanicolaou smear have never been proven through rigorous sensitivity and specificity trials and range widely depending on the study population used to derive them (3). False positive and false negative results cause unnecessary morbidity, and in some cases, mortality.
© 1998 Optical Society of America
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