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Engineering a Chromoprotein Reporter for Photoacoustic Imaging and Biosensing Applications

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Abstract

We developed a novel colony-based photoacoustic screening method to screen and evolve a chromoprotein. The improved protein was used as genetically-encoded photoacoustic reporter and utilized as a dark acceptor in FRET-based caspase-3 biosensors and Ca2+ biosensors.

© 2015 Optical Society of America

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