Label-free molecular binding assays using holographic video microscopy

Fook Chiong Cheong; David G. Grier

doi:10.1364/BODA.2011.BMD5

Optics in the Life Sciences
OSA Technical Digest (CD) (Optica Publishing Group, 2011),
paper BMD5
•https://doi.org/10.1364/BODA.2011.BMD5

Label-free molecular binding assays using holographic video microscopy

Fook Chiong Cheong and David G. Grier

Bio-Optics: Design and Application 2011

Monterey, California United States
4–6 April 2011
ISBN: 978-1-55752-909-1

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Optical Biosensors II (BMD)

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F. C. Cheong and D. G. Grier, "Label-free molecular binding assays using holographic video microscopy," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper BMD5.

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Abstract

Inline holographic video microscopy’s resolution for single particle characterization is fine enough to detect molecular-scale coatings on colloidal surfaces, without requiring staining or fluorescent labeling. We demonstrate this approach to molecular binding assay by detecting the binding of avidin to biotinylated polystyrene spheres

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