Abstract

Three-dimensional high resolution imaging methods are important for cellular level research. Optical coherence microscopy (OCM) is a scattering-based technology for cellular imaging with both high axial and lateral resolution. With a high numerical aperture objective, OCM has a shallow depth-of-field and requires scanning the focus through the entire region of interest to perform volumetric imaging. Interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) are computed imaging techniques that overcome the depth-of-field limitation and the effect of optical aberrations in optical coherence tomography (OCT), respectively. In this work we combine ISAM/CAO and OCM to achieve high-speed volumetric cellular imaging. Ex vivo images of human breast tissue and rat brain tissue are presented.

© 2014 Optical Society of America

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More Like This
Interferometric Synthetic Aperture Microscopy with Computational Adaptive Optics for High-Resolution Tomography of Scattering Tissue

Steven G. Adie, Adeel Ahmad, Nathan Shemonski, Benedikt W. Graf, Heeseok Kim, Wen-Mei W. Hwu, P. Scott Carney, and Stephen A. Boppart
BW2A.1 Biomedical Optics (BIOMED) 2012

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FM3D.3 Frontiers in Optics (FiO) 2012

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FM4D.2 Frontiers in Optics (FiO) 2012