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High spatial frequency structured light imaging negates absorption effects in fluorescence imaging

Jonathan T. Elliott, David M. McClatchy, Stephen C. Kanick, Kristian J. Sexton, Keith D. Paulsen, Venkataramanan Krishnaswamy, and Brian W. Pogue

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Abstract

Fluorescence guided surgery is hampered by absorption and scatter, which confound interpretation of fluorescence. High-frequency fluorescence structured light imaging enables real-time model-independent absorption and scatter correction.

© 2014 Optical Society of America

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