Abstract

The change in the hemoglobin concentration associated with brain activation can be obtained from the change in the reflectance of the exposed cortex and partial optical path length. A three dimensional cortical model including the blood-vessel structure is constructed to estimate the spatial distribution of the partial optical path length in the blood vessels. The change in the hemoglobin concentration in the visible blood vessels in the cortical tissue tends to be overestimated if the spatial distribution of the partial optical path length is ignored in the calculation using the modified Lambert-Beer law.

© 2014 Optical Society of America