Abstract

This talk describes the development of Diffuse Optical Spectroscopy (DOS) using spatially- and temporally-modulated sources and model-based analyses. DOS methods are capable of dynamic in vivo functional imaging with variable, but limited, spatial localization. Multiple optical contrast elements such as absorption, scattering, fluorescence, and speckle are detectable at relatively low cost. Quantitation of these signals can be achieved using methods for controlling optical path length in conjunction with computational models and visualization techniques. Article not available.

© 2012 Optical Society of America