PDT induced changes assessed by time-gated fluorescence tomography in a head and neck tumor model

Ulas Sunar; Weirong Mo; Daniel Rohrbach

doi:10.1364/BIOMED.2012.BSu5A.9

Biomedical Optics and 3-D Imaging
OSA Technical Digest (Optica Publishing Group, 2012),
paper BSu5A.9
•https://doi.org/10.1364/BIOMED.2012.BSu5A.9

PDT induced changes assessed by time-gated fluorescence tomography in a head and neck tumor model

Ulas Sunar, Weirong Mo, and Daniel Rohrbach

Biomedical Optics 2012

Miami, Florida United States
28 April–2 May 2012
ISBN: 978-1-55752-942-8

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BIOMED Postdeadline Session (BSu5A)

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U. Sunar, W. Mo, and D. Rohrbach, "PDT induced changes assessed by time-gated fluorescence tomography in a head and neck tumor model," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (Optica Publishing Group, 2012), paper BSu5A.9.

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Abstract

We report the simultaneous 3D reconstruction of fluorescence yield and lifetime of a photosensitizer (HPPH) before and after PDT. HPPH-mediated PDT induced significant changes in fluorescence yield and lifetime. This pilot study demonstrates that time-domain fluorescence tomography may be useful for assessing photosensitizer distributions in deep tissue during PDT monitoring.

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