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Conferences > BIOMED > 2012 > BSu5A > BSu5A.13

Preliminary Intravital Microscopic Analysis Reveals Specific Monocyte Uptake of Circulating Nanotubes and Peptide-Dependent Delivery into Tumor

Bryan R. Smith, Eliver Ghosn, Harikrishna Rallapalli, Jarrett Rosenberg, Jennifer Prescher, Lee Herzenberg, and Sanjiv S. Gambhir

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Abstract

Nanoparticle targeting efficiency to tumor is poor and not well-understood. Applying intravital microscopy in a mouse-model to interrogate vasculature-targeted nanotubes, we found that monocytes specifically take up nanotubes and are programmed to enter tumor.

© 2012 Optical Society of America

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