Near-Infrared, Diffuse-Correlation-Spectroscopy evaluation of cerebral hemodynamics with Acetazolamide challenge in healthy and acute ischemic stroke subjects

Peyman Zirak; Raquel Delgado-Mederos; Udo Weigel; Mehmet Süzen; Joan Martí-Fàbregas; Turgut Durduran

doi:10.1364/BIOMED.2010.BWF4

Biomedical Optics and 3-D Imaging
OSA Technical Digest (CD) (Optica Publishing Group, 2010),
paper BWF4
•https://doi.org/10.1364/BIOMED.2010.BWF4

Near-Infrared, Diffuse-Correlation-Spectroscopy evaluation of cerebral hemodynamics with Acetazolamide challenge in healthy and acute ischemic stroke subjects

Peyman Zirak, Raquel Delgado-Mederos, Udo Weigel, Mehmet Süzen, Joan Martí-Fàbregas, and Turgut Durduran

Biomedical Optics 2010

Miami, Florida United States
11–14 April 2010
ISBN: 978-1-55752-887-2

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Clinical Applications of Diffuse Optics I (BWF)

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P. Zirak, R. Delgado-Mederos, U. Weigel, M. Süzen, J. Martí-Fàbregas, and T. Durduran, "Near-Infrared, Diffuse-Correlation-Spectroscopy evaluation of cerebral hemodynamics with Acetazolamide challenge in healthy and acute ischemic stroke subjects," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper BWF4.

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Abstract

We combine diffuse-correlation-spectroscopy, near-infrared-spectroscopy and tran-scranial Doppler (TCD) techniques to measure cerebral blood flow (CBF) and cerebral blood flow velocity (CBFV) in healthy and acute ischemic stroke patients to assess cerebrovascular reactivity (CVR). Intravenous administration of Acetazolamide (AZ) is used to stimulate cerebral vasculature. So far the measurements on three healthy subjects showed good agreement between diffuse optic and TCD measurements. An average of 45 % change in CBF and CBFV after AZ administration is obtained which is in good agreement with the literature.

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