Living Motion as Label-Free Imaging Contrast in Three-Dimensional Tissue-Based Drug Screening

David D. Nolte; Kwan Jeong; John Turek

doi:10.1364/BIOMED.2010.BTuF2

Biomedical Optics and 3-D Imaging
OSA Technical Digest (CD) (Optica Publishing Group, 2010),
paper BTuF2
•https://doi.org/10.1364/BIOMED.2010.BTuF2

Living Motion as Label-Free Imaging Contrast in Three-Dimensional Tissue-Based Drug Screening

David D. Nolte, Kwan Jeong, and John Turek

Biomedical Optics 2010

Miami, Florida United States
11–14 April 2010
ISBN: 978-1-55752-887-2

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Biological and Drug Discovery Imaging (BTuF)

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D. D. Nolte, K. Jeong, and J. Turek, "Living Motion as Label-Free Imaging Contrast in Three-Dimensional Tissue-Based Drug Screening," in Biomedical Optics and 3-D Imaging, OSA Technical Digest (CD) (Optica Publishing Group, 2010), paper BTuF2.

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Abstract

Motility contrast imaging (MCI) detects sub-cellular motion in living tissue as a fully endogenous imaging contrast agent. Three-dimensional imaging assays of anti-mitotic cancer drugs have extracted label-free functional signatures in tumors for the first time.

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