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3D visualization of intrinsic contrast in neoplastic colon tissue using hyperspectral two-photon microscopy

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Abstract

Hyperspectral two-photon imaging of endogenous fluorescence and SHG allows 3D visualization of gastrointestinal tissue without slicing or staining. A study of the morphological changes that occur in two mouse models of cancer is presented.

© 2010 Optical Society of America

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