Quantification of Dendrimer Nanoparticle Targeting on Tumor Cells by Two-photon Excitation Fluorescence through a Dual-Clad Optical Fiber

Yu-Chung Chang; Thommey P. Thomas; Jing Yong Ye; Jing Yong Ye; Alina Kotlyar; Zhengyi Cao; Istvan J. Majoros; James R. Baker; Theodore B. Norris; Theodore B. Norris

doi:10.1364/BIOMED.2008.BSuE4

Biomedical Optics
OSA Technical Digest (CD) (Optica Publishing Group, 2008),
paper BSuE4
•https://doi.org/10.1364/BIOMED.2008.BSuE4

Quantification of Dendrimer Nanoparticle Targeting on Tumor Cells by Two-photon Excitation Fluorescence through a Dual-Clad Optical Fiber

Yu-Chung Chang, Thommey P. Thomas, Jing Yong Ye, Alina Kotlyar, Zhengyi Cao, Istvan J. Majoros, James R. Baker, and Theodore B. Norris

Biomedical Optics 2008

St. Petersburg, Florida United States
16–19 March 2008
ISBN:

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BIOMED Poster Session I (BSuE)

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Y. Chang, T. P. Thomas, J. Y. Ye, A. Kotlyar, Z. Cao, I. J. Majoros, J. R. Baker, and T. B. Norris, "Quantification of Dendrimer Nanoparticle Targeting on Tumor Cells by Two-photon Excitation Fluorescence through a Dual-Clad Optical Fiber," in Biomedical Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2008), paper BSuE4.

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Abstract

We report the use of a dual-clad optical fiber to conduct quantitative two-photon excited fluorescence measurements in vitro and in vivo inside tumors. The ability to detect nanomolar concentrations of tumor cell targeting nanoparticles with this dual-clad fiber scheme is confirmed. The results indicate that this technique is an appropriate tool to quantify low concentrations of targeted fluorescence probes in vivo in deep tissue.

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