We present a frequency domain imaging system that allows for two-dimensional detection of phase and amplitude information up to 1 GHz. This is achieved by modulating the gain of an intensifier in front of a CCD camera that is operated in a homodyne mode. The system performance was investigated and characterized by taking measurements on optical tissue phantoms. Furthermore, we determined what modulation frequencies lead to the best signal-to-noise ratio in small tissue geometries, typically encountered in small animal and finger joint imaging.

© 2008 Optical Society of America

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