Abstract

The changes in the oxy- and deoxy-haemoglobins in the cortical tissue caused by brain functions have been measured by multi-spectral imaging of the exposed cortex. It is important for the accurate measurement of the concentration changes in the oxy- and deoxy-haemoglobins to consider the wavelength dependence of the mean optical path lengths of the detected light. In this study, the changes in the cerebral haemoglobin concentrations of guinea pigs are measured using a multi-spectral imaging system. The wavelength dependence of the optical path lengths is estimated from the multi-spectral image of the exposed cortex in order to improve the haemoglobin concentration measurement

© 2006 Optical Society of America