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Conferences > BIO > 2006 > TuC > TuC2

Non-invasive, continuous monitoring of a vascular targeting drug by diffuse optical blood flow and blood oxygenation measurements

U. Sunar, S. Makonnent, H. W. Wang, T. Durduran, C. Zhou, G. Yu, W. M. F. Leet, and A. G. Yodh

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Abstract

Here we present a pilot study on vascular targeting drug combretastatin A4- phosphate (CA4P) in K1735 malignant melanoma tumor models. The results show that CA4P induces a drastic decrease in blood flow and oxygen saturation. These results correlated well with contrast enhanced Ultrasound and nitroimidazole (EF5) binding.

© 2006 Optical Society of America

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