Abstract
The transition from probe-based spectroscopy to non-contact spectral imaging for brain tumor demarcation induces changes in fluorescence and diffuse reflectance lineshape. Initial results demonstrate these changes are due to the disparity in excitation-collection geometry between the two optical biopsy systems. A thorough investigation of this phenomenon and strategies to correct for these effects will allow discrimination algorithms determined from our multi-center clinical trials using probe-based spectroscopy to be applied for surgical guidance using spectral imaging.
© 2006 Optical Society of America
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