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Epi-illumination darkfield through a microscope objective for imaging and spectral analysis of nanoparticle interaction with cells in culture

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Abstract

Existing darkfield illumination schemes are incompatible with many types of samples and/or procedures. We present a darkfield scheme which addresses these incompatibilities. We then apply the scheme to evaluate nanoparticles binding cancer cells in culture.

© 2006 Optical Society of America

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