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Optical Stimulation of Peripheral Nerves In Vivo

Jonathon Wells, Chris Kao, Duco Jansen, Peter Konrad, and Anita Mahadevan-Jansen

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Abstract

A novel method of stimulation of neural tissue using pulsed, low-energy laser light is presented. Optical stimulation elicits compound nerve and muscle action potentials, with resultant muscle contraction, similar to responses obtained with conventional electrical stimulation of the nerve. Results indicate wavelength dependence of optical stimulation and stimulation thresholds from 0.312 J/cm2 (λ=3μm) to 1.02 J/cm2 (λ=4μm) with the largest ratio of damage/stimulation threshold (>5) at absorption valleys in soft tissue (4 and 2.1 μm).

© 2004 Optical Society of America

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