A hybrid instrument combining near-infrared diffuse reflection spectroscopy and diffuse correlation spectroscopy (DCS) was used to simultaneously measure the concentration, oxygenation, and flow characteristics of blood cells in the same region of human skeletal muscles. The signals detected from different layers (skin, subcutaneous fat and muscle) were analyzed and the strongest response was found from muscle. The use of this hybrid instrument was demonstrated by characterizing the hemodynamic responses of nine healthy subjects and one patient with peripheral vascular disease (PVD) during arterial cuff occlusion of arm or leg and during plantar flexion exercise.

© 2004 Optical Society of America

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