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Assessment of cerebral perfusion by time-resolved diffuse NIR-reflectance following injection of a dye-bolus

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Abstract

We monitored the passage of an indocyanine green (ICG) bolus through the brain and extracerebral tissue in healthy volunteers by means of time-resolved diffuse NIR-reflectance measurements. The latency of the bolus as calculated from changes in attenuation of the diffusely reflected light depends significantly on the detector position on the head, whereas it is almost independent of position when the variance of the distribution of times of flight of photons is analyzed.

© 2004 Optical Society of America

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