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We used near-infrared spectroscopy to separate tissue scattering changes from changes in cerebral oxy- and deoxyhemoglobin and the redox state of Cytochrome-c-oxidase during cortical spreading depression (CSD) in barbiturate anesthetized rats. A separate term for the transport scattering coefficient (µs’) was added in a modified Lambert-Beer equation where the differential pathlength factor (Da) and its scattering equivalent (Ds) are included. During CSDs recorded through the skull of rats strong biphasic changes in µs’ of about ± 0.1 mm-1 were observed that spread with a velocity of about 5 mm/min. It is shown that the DC potential recorded on the skull has a strong correlation with the scattering properties. This was found during CSDs as well as during the period of the anoxic cell depolarisation after sacrificing the animal.
© 1998 Optical Society of America
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