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In-Vivo Catheter-Based Imaging with Optical Coherence Tomography

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Abstract

The high incidence and mortality rate associated with complications resulting from coronary artery atherosclerosis dictate an important and immediate need for a new, high resolution, diagnostic imaging technology that would allow characterization of artery microstructure with a micron scale resolution. OCT allows catheter based, cross-sectional imaging of blood vessels with a 10-20 µm resolution and is ideally suited for in vivo imaging of arterial structure. Recently, OCT imaging was extended to in vitro pathology, including multiple studies on atherosclerotic arteries. OCT has also been directly compared with a 30 MHz, IVUS transducer. In addition to qualitatively superior resolution with respect to imaging plaque, OCT was demonstrated to be quantitatively superior. In vivo imaging was performed on normal, New Zealand White rabbits using a novel rapid data acquisition system which allows imaging at 4 frames per second. This work, focusing on dynamic changes, demonstrates that high resolution intravascular imaging can be performed in vivo using optical coherence tomography. Images at 10 µm resolution were obtained, representing an improvement of over 10X that of 'state of the art' IVUS transducers.

© 1998 Optical Society of America

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