Molecular imaging has drawn increasing interest in clinical diagnosis because it enables the visualization of specific markers that track disease progression at the cellular and sub-cellular level. The intersection of wide-field fluorescence endoscopic imaging and molecular biology opens up great potential for early cancer detection, quantitative assessments and more targeted/personalized treatment of diseases based on their specific molecular expression profiles. This talk will cover technologies and methodologies developed for the applications of an ultrathin and flexible multispectral Scanning Fiber Endoscope (SFE) system, including the development of universal calibration standards for quality assurance, quantitative fluorescence wide-field imaging, and image stitching to produce a panorama for inspections of small ducts and cavities in the body.

© 2014 Optical Society of America

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