We have used diffusion theory to model the fluorescence photon density inside a strongly scattering medium containing multiple fluorophores. Frequency- domain parameters were measured as functions of source-detector separation and modulation frequency inside in a turbid medium containing two fluorophores. Our theoretical prediction, based on a model originally proposed by Patterson and Pogue, was found to be in excellent agreement with the experimental data.

© 1998 Optical Society of America

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