Abstract

Observation and characterization of any changes in anatomical structures of ocular components remain as a conventional technique for diagnosis, staging, therapeutic treatments, and post-treatment monitoring of any ophthalmic disorders. The existing technologies fail to provide imaging of all of the various components of the eye simultaneously at one scanning time, i.e., one can recover vital patho-physiological information (structure and bio-molecular content) of the different ocular tissue sections only one after another. This article addresses the longstanding technological challenge by use of an emerging imaging modality [photoacoustic imaging (PAI)] in which we integrated a synthetic aperture reconstruction technique (SAFT). Experimental results—with experiments being conducted in excised tissues (goat eye)—demonstrated that we can simultaneously image the entire structure of the eye (∼2.5 cm) depicting clearly the distinctive ocular structures (cornea, aqueous humor, iris, pupil, eye lens, vitreous humor, and retina). This study uniquely opens an avenue for promising ophthalmic (clinical) applications of high clinical impact.

© 2023 Optica Publishing Group

Label-free, non-contact, in vivo ophthalmic imaging using photoacoustic remote sensing microscopy

Zohreh Hosseinaee, Layla Khalili, James A. Tummon Simmons, Kevan Bell, and Parsin Haji Reza
Opt. Lett. 45(22) 6254-6257 (2020)

Ultracompact high-resolution photoacoustic microscopy

Qian Chen, Heng Guo, Tian Jin, Weizhi Qi, Huikai Xie, and Lei Xi
Opt. Lett. 43(7) 1615-1618 (2018)

High-resolution dual-modality photoacoustic ocular imaging

Ning Wu, Shuoqi Ye, Qiushi Ren, and Changhui Li
Opt. Lett. 39(8) 2451-2454 (2014)

Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging

Tian Jin, Heng Guo, Huabei Jiang, Bowen Ke, and Lei Xi
Opt. Lett. 42(21) 4434-4437 (2017)

Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

Xiaojing Liu, Tan Liu, Rong Wen, Yiwen Li, Carmen A. Puliafito, Hao F. Zhang, and Shuliang Jiao
Opt. Lett. 40(7) 1370-1373 (2015)