Abstract
The pleura is known as an end target organ of exposure to toxic
environmental materials such as fine particulate matter and asbestos.
Moreover, long-term exposure to hazardous materials can eventually lead to
fatal lung disease such as diffuse pleural fibrosis or mesothelioma. Chest
computed tomography (CT) and ultrasound are gold standard imaging
modalities for detection of advanced pleural disease. However, a
diagnostic tool for early detection of pleural reaction has not been
developed yet due to difficulties in imaging ultra-fine structure of the
pleura. Optical coherence tomography (OCT), which provides cross-sectional
images of micro tissue structures at a resolution of 2-10 µm, can
image the mesothelium with a thickness of ~100 µm and therefore
enables investigation of the early pleural reaction. In this study, we
induced the early pleural reaction according to a time sequence after
pleurodesis using talc, which has been widely used in the clinical field.
The pleural reaction in talc grouped according to the time sequence (1st,
2nd, 4th weeks) showed a significant thickening (average thickness: 45
± 7.5 µm, 80 ± 10.7 µm, 90 ± 12.5 µm), while
the pleural reaction in sham and normal groups showed pleural change from
normal to minimal thickening (average thickness: 16 ± 5.5 µm, 17
± 4.5 µm, 15 ± 6.5 µm, and 12 ± 7.5 µm, 13
± 2.5 µm, 12 ± 3.5 µm). The measurement of pleural
reaction by pathologic examinations was well-matched with the measurement
by OCT images. This is the first study for measuring the thickness of
pleural reactions using a biophotonic modality such as OCT. Our results
showed that OCT can be useful for evaluating the early pleural
reaction.
© 2016 Optical Society of Korea
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