Abstract
Disintegrating agents, such as microcrystalline cellulose (MCC), starch, carboxymethyl cellulose (CMC) and polyvinylpyrrolidone, are often used as drug additives to make the tablet swell and disintegrate in water. Here, we investigated the swelling process of these agents via near infrared and two-dimensional correlation spectroscopic analysis. The traditional agents MCC and starch showed increments of loose hydration prior to strong hydration. However, strong hydration increases were followed by loose hydration for CMC. In conclusion, the distinguishing swelling property of CMC is provided by the first strong hydration of water molecules, which may avoid polymer–polymer interaction and induce water penetration into the drug tablet.
© 2014 IM Publications LLP
PDF Article
More Like This
Cited By
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Login to access Optica Member Subscription