Abstract
This paper presents a new biophotonic application for large-area, high-resolution,
flexible organic light-emitting diode (OLED) display technology currently
used to manufacture low-cost color flexible displays on plastic substrates.
The new concept uses a fully addressable high resolution flexible OLED pixel
array on a thin, mechanically compliant biocompatible plastic substrate to
selectively stimulate and/or silence small groups of neurons on either the
cortical surface or, alternatively, within the deep brain. Optical measurements
from a 455 nm blue flexible OLED test structure demonstrated the ability to
emit 1
${{mW/mm}}^{2}$
of instantaneous light intensity using a 13 V, 20 Hz pulse, which
meets the minimum reported intensity at
$\sim$
450 nm to induce optical stimulation
in genetically modified neural tissue. Biocompatibility was successfully demonstrated
by the ability to grow human epithelial cells on the surface of a full TFT
process flow plastic flexible display substrate. Additionally, a new active
matrix array display architecture was designed to support pulsed mode OLED
operation. These preliminary results demonstrate the initial viability of
extending flexible plastic substrate OLED display technology to the development
of large-area, high-resolution emissive active matrix arrays for chronic optogenetic
applications.
© 2014 IEEE
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