Abstract

This study investigated the feasibility of photoacoustic (PA) imaging of bone and characterization of bone features. By conducting the experiments on bovine femoral heads ex vivo, the light and ultrasonic penetration in bones was studied, together with the depth of PA imaging and measurement in bones. Then, the possibility of three-dimensional (3D) PA imaging of bones by raster scanning of the focusing transducer was studied. The micro-computerized tomography images of the bovine ribs with and without ethylenediaminetetraacetic acid (EDTA) treatment indicated that the 3D PA images could present the changes of bone microstructure resulting from the EDTA treatment. By using PA spectral analysis, the bone samples with and without the treatment of EDTA solution can be distinguished, and the microstructures can be characterized. This study was based on the bovine bone whose size is comparable to human bones, suggesting that PA technology can be used as a novel bone diagnostic technique.

© 2020 Chinese Laser Press

Characterization of bone microstructure using photoacoustic spectrum analysis

Ting Feng, Joseph E. Perosky, Kenneth M. Kozloff, Guan Xu, Qian Cheng, Sidan Du, Jie Yuan, Cheri X. Deng, and Xueding Wang
Opt. Express 23(19) 25217-25224 (2015)

Photoacoustic characterization of bone physico-chemical information

Weiya Xie, Ting Feng, Dong Yu, Dean Ta, Liming Cheng, and Qian Cheng
Biomed. Opt. Express 13(5) 2668-2681 (2022)

Photothermal tomography for the functional and structural evaluation, and early mineral loss monitoring in bones

Sreekumar Kaiplavil, Andreas Mandelis, Xueding Wang, and Ting Feng
Biomed. Opt. Express 5(8) 2488-2502 (2014)

Bone assessment via thermal photo-acoustic measurements

Ting Feng, Kenneth M. Kozloff, Chao Tian, Joseph E. Perosky, Yi-Sing Hsiao, Sidan Du, Jie Yuan, Cheri X. Deng, and Xueding Wang
Opt. Lett. 40(8) 1721-1724 (2015)

Assessment of liver function reserve by photoacoustic tomography: a feasibility study

Tingting Qiu, Jinge Yang, Teng Pan, Chihan Peng, Huabei Jiang, and Yan Luo
Biomed. Opt. Express 11(7) 3985-3995 (2020)