Abstract
Optical birefringence is a valuable parameter in evaluating collagen organization and assessing collagen degeneration in articular cartilage. A uniaxial birefringent model is implied when using existing methods such as polarized light microscopy in characterizing birefringence in cartilage. However, some studies suggest the existence of a sheet-like collagen organization in articular cartilage, which requires a biaxial birefringence model to describe. In this study, we applied a multi-incident birefringence measurement procedure to investigate the biaxial birefringence in articular cartilage. The results supported the existence of a small yet significant biaxial birefringence effect, which was in agreement with the expectation from a sheet-like collagen organization.
© 2019 Optical Society of America
Full Article | PDF ArticleMore Like This
Mohammadreza Ravanfar and Gang Yao
Biomed. Opt. Express 10(7) 3241-3256 (2019)
R. N. Huynh, B. Pesante, G. Nehmetallah, and C. B. Raub
Biomed. Opt. Express 10(11) 5518-5534 (2019)
Bilour Khan, Ervin Nippolainen, Fatemeh Shahini, Jari Torniainen, Santtu Mikkonen, Nonappa, Alexey Popov, Juha Töyräs, and Isaac O. Afara
J. Opt. Soc. Am. A 40(12) 2205-2214 (2023)