Abstract
We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ~1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter (200 µm). The depth resolution is ~10 µm.
© 1998 Optical Society of America
Full Article | PDF ArticleMore Like This
Zhongwei Zhi, Yeongri Jung, and Ruikang K. Wang
Opt. Lett. 37(5) 812-814 (2012)
Hideaki Haneishi, Tadaaki Masuda, Nagaaki Ohyama, and Toshio Honda
Opt. Lett. 14(20) 1095-1097 (1989)
Geng Ku and Lihong V. Wang
Opt. Lett. 30(5) 507-509 (2005)