Abstract

Sensitivity is an important parameter to characterize the performance of sensors. Interfacial modification and functionalization is an effective strategy to improve the sensitivity of optical biosensors. This paper reports our recent development on interface sensitized fiber optic biosensors for the detection of ultra-low concentration of biological targets. We employ microfiber mode interferometer as transducer to sense the molecular binding interaction induced surrounding refractive index change. By modifying the microfiber surface to increase the assembling surface area and enhance the evanescent field energy density, ultra-low limit of detection of 1.65 × 10⁻¹⁵ M and 6.82 × 10⁻¹⁷ M, respectively, were realized for neurotransmitter γ-amino-butyric acid and cellular cytochrome c.

© 2018 OAPA

Au-NPs signal amplification ultra-sensitivity optical microfiber interferometric biosensor

Hanglin Lu, Runjia Liu, Peiyuan Liu, Wenfu Lin, Yan Huang, Ruitao Xiao, Zhenru Li, Jun Ma, Wei Wang, Jie Li, Li-Peng Sun, and Bai-Ou Guan
Opt. Express 29(9) 13937-13948 (2021)

Mesoporous nanospheres functionalized optical microfiber biosensor for low concentration neurotransmitter detection

Mingfei Ding, Yunyun Huang, Tuan Guo, Li-Peng Sun, and Bai-Ou Guan
Opt. Express 24(24) 27152-27159 (2016)

High-sensitivity DNA biosensor based on microfiber Sagnac interferometer

Shuai Gao, Li-Peng Sun, Jie Li, Long Jin, Yang Ran, Yunyun Huang, and Bai-Ou Guan
Opt. Express 25(12) 13305-13313 (2017)

High-sensitivity DNA biosensor based on optical fiber taper interferometer coated with conjugated polymer tentacle

Yunyun Huang, Zhuang Tian, Li-Peng Sun, Dandan Sun, Jie Li, Yang Ran, and Bai-Ou Guan
Opt. Express 23(21) 26962-26968 (2015)

Modulation instability and highly sensitive optical fiber biosensor

S. A. Madani, M. Bahrami, and A. Rostami
Opt. Continuum 1(4) 816-825 (2022)